Database : HANSEN Search on : DADOS DE SEQUENCIA MOLECULAR [Subject descriptor] References found : 81 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 18226 Author: Vardhini, Deena; Suneetha, Sujai; Ahmed, Niyaz; Joshi, D. S. M; Karuna, S; Magee, X; Vijayalakshmi, D. S. R; Sridhar, V; Karunakar, K. V; Archelos, Juan J; Suneetha, Lavanya M Title: Comparative proteomics of the Mycobacterium leprae binding protein myelin P0: its implication in leprosy and other neurodegenerative diseases ..- Source: s.l; s.n; 2004. 8 p. ilus, tab. Abstract: Mycobacterium leprae, the causative agent of leprosy invades Schwann cells of the peripheral nerves leading to nerve damage and disfigurement, which is the hallmark of the disease. Wet experiments have shown that M. leprae binds to a major peripheral nerve protein, the myelin P zero (P0). This protein is specific to peripheral nerve and may be important in the initial step of M. leprae binding and invasion of Schwann cells which is the feature of leprosy. Though the receptors on Schawann cells, cytokines, chemokines and antibodies to M. leprae have been identified the molecular mechanism of nerve damage and neurodegeneration is not clearly defined. Recently pathogen and host protein/nucleotide sequence similarities (molecular mimicry) have been implicated in neurodegenerative diseases. The approach of the present study is to utilise bioinformatic tools to understand leprosy nerve damage by carrying out sequence and structural similarity searches of myelin P0 with leproma and other genomic database. Since myelin P0 is unique to peripheral nerve, its sequence and structural similarities in other neuropathogens have also been noted. Comparison of myelin P0 with the M. leprae proteins revealed two characterised proteins, Ferrodoxin NADP reductase and a conserved membrane protein, which showed similarity to the query sequence. Comparison with the entire genomic database (www.ncbi.nlm.nih.gov) by basic local alignment search tool for proteins (BLASTP) and fold classification of structure-structure alignment of proteins (FSSP) searches revealed that myelin P0 had sequence/structural similarities to the poliovirus receptor, coxsackie-adenovirus receptor, anthrax protective antigen, diphtheria toxin, herpes simplex virus, HIV gag-1 peptide, and gp120 among others. These proteins are known to be associated directly or indirectly with neruodegeneration. Sequence and structural similarities to the immunoglobin regions of myelin P0 could have implications in host-pathogen interactions, as it has homophilic adhesive properties. Although these observed similarities are not highly significant in their percentage identity, they could be functionally important in molecular mimicry, receptor binding and cell signaling events involved in neurodegeneration. (AU). Descriptors: Sequência de Aminoácidos Proteínas de Bactérias/GE/ME Biologia Computacional Hanseníase/*ME/MI Proteínas de Membrana/* Modelos Moleculares Mimetismo Molecular Dados de Sequência Molecular Mycobacterium leprae/*GE/ME Proteína P0 da Mielina/CH/*GE/ME Doenças Neurodegenerativas/*ME Ligação Proteica Conformação Proteica Proteômica/* Receptores Virais/CH/ME Limits: HUMANO Location: BR191.1; 09195/S

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Id: 17564 Author: Kramme, Stefanie; Bretzel, Gisela; Panning, Marcus; Kawuma, Joseph; Drosten, Christian Title: Detection and quantification of Mycobacterium leprae in tissue samples by real-time PCR ..- Source: s.l; s.n; 2004. 5 p. tab, graf. Abstract: Real-time PCR technology has improved molecular diagnostics of many pathogens, but no such test is available for Mycobacterium leprae. In this report we describe the establishment and the pre-clinical evaluation of such an assay. The test achieved a theoretical analytical sensitivity limit of 194 M. leprae cells per skin biopsy specimen and facilitated quantification of mycobacteria in tissue over a range of 54-54,000,000 cells per sample. In punch skin biopsies from 39 untreated Ugandan patients with newly diagnosed leprosy, the clinical diagnosis could be confirmed in 88.9% of multibacillary and 33.3% of paucibacillary (microscopically negative) patients. Real-time detection thus did not increase the clinical sensitivity of PCR as compared to conventional protocols, in spite of its evidently high analytical sensitivity. On the other hand, as still no culture system exists for M. leprae, the assay appears to be a robust tool for detection of the bacterium in selected clinical situations, as well as for quantitation in experimental settings. (AU). Descriptors: Antígenos de Bactérias/GE Proteínas de Bactérias/GE Biópsia DNA Bacteriano/CH/IP Hanseníase/*DI/MI Dados de Sequência Molecular Mycobacterium leprae/GE/*IP Reação em Cadeia da Polimerase/*MT Sensibilidade e Especificidade Alinhamento de Sequência Análise de Sequência de DNA Pele/MI Uganda Limits: Research Support, Non-U.S. Gov't Humanos Location: BR191.1; 09344/s

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Id: 17562 Author: Kang, Tae Jin; Yeum, Chung Eun; Kim, Byoung Chul; You, Eun-Young; Chae, Gue-Tae Title: Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation ..- Source: s.l; s.n; 2004. 7 p. ilus, tab, graf. Abstract: Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infection with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-alpha in response to Mycobacterium leprae in peripheral blood mononuclear cells (PBMC) with the TLR2 mutation Arg677Trp, a recently reported polymorphism that is associated with lepromatous leprosy. In leprosy patients with the TLR2 mutation, production of IL-2, IL-12, IFN-gamma, and TNF-alpha by M. leprae-stimulated PBMC were significantly decreased compared with that in groups with wild-type TLR2. However, the cells from patients with the TLR2 mutation showed significantly increased production of IL-10. There was no significant difference in IL-4 production between the mutant and wild-type during stimulation. Thus, these results suggest that the TLR2 signal pathway plays a critical role in the alteration of cytokine profiles in PBMC from leprosy patients and the TLR2 mutation Arg677Trp provides a mechanism for the poor cellular immune response associated with lepromatous leprosy. (AU). Descriptors: Sequência de Bases Interleucina-10/*BI Interleucina-12/*BI Hanseníase/GE/*IM Leucócitos Mononucleares/IM Glicoproteínas de Membrana/*GE/ME Camundongos Nus Dados de Sequência Molecular Mutação Puntual/* Receptores da Superfície Celular/*GE/ME Receptor 2 Toll-Like Receptores Toll-Like Fator de Necrose Tumoral alfa/BI Limits: Adulto Idoso Animais Feminino Humanos Masculino Camundongos Research Support, Non-U.S. Gov't Meia-Idade Location: BR191.1; 09341/s

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Id: 17561 Author: Geluk, A; van Meijgaarden, K. E; Franken, K. L. M. C; Wieles, B; Arend, S. M; Faber, W. R; Naafs, B; Ottenhoff, T. H. M Title: Immunological crossreactivity of the Mycobacterium leprae CFP-10 with its homologue in Mycobacterium tuberculosis ..- Source: s.l; s.n; 2004. 5 p. tab, graf. Abstract: Mycobacterium tuberculosis culture filtrate protein-10 (CFP-10) (Rv3874) is considered a promising antigen for the immunodiagnosis of tuberculosis (TB) together with early secreted antigens of M. tuberculosis (ESAT-6). Both ESAT-6 and CFP-10 are encoded by the RD1 region that is deleted from all tested M. bovis bacille Calmette-Guérin (BCG) strains but present in M. leprae, M. tuberculosis, M. bovis, M. kansasii, M. africanum and M. marinum. In this study, the homologue of CFP-10 in M. leprae (ML0050) is identified and characterized. Interferon-gamma production in response to this homologue by T cells from leprosy patients, TB patients and unexposed controls shows that CFP-10 of M. leprae is a potent antigen that crossreacts with CFP-10 of M. tuberculosis at the T-cell level. This crossreactivity has implications for the use of CFP-10 of these mycobacterial species as diagnostic tool in areas endemic for both the diseases. (AU). Descriptors: Sequência de Aminoácidos Antígenos de Bactérias/IM Proteínas de Bactérias/*IM Reações Cruzadas/IM Interferon Tipo II/IM/SE Hanseníase/*IM Ativação Linfocítica/IM Dados de Sequência Molecular Mycobacterium leprae/*IM Mycobacterium tuberculosis/*IM Homologia de Sequência Linfócitos T/IM/ME Tuberculose/*IM Limits: Research Support, Non-U.S. Gov't Humanos Estudo Comparativo Animais Location: BR191.1; 09340/s

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Id: 13722 Author: Maeda, Yumi; Makino, Masahiko; Crick, Dean C; Mahapatra, Sebabrata; Srisungnam, Sopa; Takii, Takemasa; Kashiwabara, Yoshiko; Brennan, Patrick J Title: Novel 33-kilodalton lipoprotein from Mycobacterium leprae ..- Source: s.l; s.n; 2002. 6 p. tab, graf. Abstract: A novel Mycobacterium leprae lipoprotein LpK (accession no. ML0603) was identified from the genomic database. The 1,116-bp open reading frame encodes a 371-amino-acid precursor protein with an N-terminal signal sequence and a consensus motif for lipid conjugation. Expression of the protein, LpK, in Escherichia coli revealed a 33-kDa protein, and metabolic labeling experiments and globomycin treatment proved that the protein was lipidated. Fractionation of M. leprae demonstrated that this lipoprotein was a membrane protein of M. leprae. The purified lipoprotein was found to induce production of interleukin-12 in human peripheral blood monocytes. The studies imply that M. leprae LpK is involved in protective immunity against leprosy and may be a candidate for vaccine design. (AU). Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTERIAS/GE/*IM/IP PROTEINAS DE BACTERIAS/GE/*IM/IP CLONAGEM MOLECULAR ESCHERICHIA COLI EXPRESSAO GENICA GENES BACTERIANOS INTERLEUCINA-12/*BI LIPOPROTEINAS/GE/*IM/IP PROTEINAS DE MEMBRANA/GE/*IM/IP DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MONOCITOS/IM MYCOBACTERIUM LEPRAE/GE/*IM/IP PRECURSORES DE PROTEINAS/GE/*IM/IP ANALISE DE SEQUENCIA DE DNA Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Location: BR191.1; 09059/s

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Id: 13666 Author: Bala, Lakshmi; Anand, Sukumar; Sinha, Sudhir Title: Enhancement of human T cell response to a peptide epitope of 38kDa antigen of Mycobacterium tuberculosis by liposomes ..- Source: s.l; s.n; 2002. 9 p. graf. Abstract: Diagnosis of tuberculosis a problem, specially in the regions harboring an abundance of both pathogenic and non-pathogenic mycobacteria. This study was undertaken to assess in such a situation the predictive value of proliferative T cell response to a peptide epitope ('38G') of the 38 kDa membrane protein of Mycobacterium tuberculosis. 3[H]-thymidine incorporation assays were done with peripheral blood mononuclear cells of tuberculoid leprosy and pulmonary tuberculosis patients. The donors were also classified as PPD responders (Stimulation Index, SI> 3) or non-responders (SI < or = 3) on the basis of their T cell response to the 'Purified Protein Derivative (PPD)' of M. tuberculosis. 38G peptide was used in either free or liposome-associated form prepared by the technique of 'Dehydration-rehydration Vesicles' (Kirby and Gregoriadis, 1984). While free peptide failed to induce a positive response in study subjects, its liposomal form was T cell stimulatory and distinguished, to certain extent, between PPD responders (corresponding SI > 3 in 54 per cent subjects) and non-responders (SI > 3 in 29 per cent subjects). However, it did not differentiate between leprosy and tuberculosis. The study supports use of liposomes as adjuvant vehicles for antigenic peptides designed to activate human T cells. (AU). Descriptors: ANTIGENOS DE BACTERIAS/admin ANTIGENOS DE BACTERIAS/quim ANTIGENOS DE BACTERIAS/genet HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol EPITOPOS/admin EPITOPOS/quim EPITOPOS/genet DIAGNOSTICO DIFERENCIAL MYCOBACTERIUM TUBERCULOSIS/quim MYCOBACTERIUM TUBERCULOSIS/genet MYCOBACTERIUM TUBERCULOSIS/imunol DADOS DE SEQUÊNCIA MOLECULAR SEQUÊNCIA DE AMINOACIDOS LINFOCITOS T/imunol TESTE TUBERCULINICO TUBERCULOSE PULMONAR/diag TUBERCULOSE PULMONAR/imunol TRANSFORMACAO LINFOCITICA - LIPOSSOMOS  PESO MOLECULAR Limits: ESTUDO COMPARATIVO HUMANO IN VITRO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09061/s

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Id: 12297 Author: Spencer, John S; Marques, Maria Angela M; Lima, Monica C. B. S; Junqueira_Kipnis, Ana Paula; Gregory, Bruce C; Truman, Richard W; Brennan, Patrick J Title: Antigenic specificity of the mycobacterium leprae homologue of ESAT-6 ..- Source: s.l; s.n; Feb. 2002. 4 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ESPECIFICIDADE DE ANTICORPOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS CLONAGEM MOLECULAR EPITOPOS DE LINFOCITO B EPITOPOS DE LINFOCITO B EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C DADOS DE SEQUENCIA MOLECULAR Limits: ANIMAL Location: BR191.1; 08667/s

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Id: 12278 Author: Kang, Tae-Jin; Chae, Gue-Tae Title: Detection of toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients ..- Source: s.l; s.n; 2001. 6 p. ilus, tab. Descriptors: SEQUENCIA DE AMINOACIDOS HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES GLICOPROTEINAS DE MEMBRANAS GLICOPROTEINAS DE MEMBRANAS DADOS DE SEQUENCIA MOLECULAR MUTAÇAO MYCOBACTERIUM LEPRAE POLIMORFISMO CONFORMACIONAL DE SIMPLES FITA RECEPTORES DA SUPERFICIE CELULAR RECEPTORES DA SUPERFICIE CELULAR ALINHAMENTO DE SEQUENCIA TRANSDUÇAO DE SINAL Location: BR191.1; 08630/s

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Id: 12248 Author: Williams, Diana L; Pittman, Tana L; Gillis, Thomas P; Matsuoka, Masanori; Kashiwabara, Yoshiko Title: Simultaneous detection of mycobacterium leprae and its susceptibility to dapsone using DNA heteroduplex analysis ..- Source: s.l; s.n; Jun. 2001. 6 p. ilus, tab. Descriptors: SEQUENCIA DE BASES DNA BACTERIANO DNA BACTERIANO DAPSONA RESISTENCIA MICROBIANA A DROGAS LEPROSTATICOS HANSENIASE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE SENSIBILIDADE E ESPECIFICIDADE ANALISE DE SEQUENCIA DE DNA Análise Heteroduplex/*MT Location: BR191.1; 08678/s; BR191.1; 08430/s

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Id: 12245 Author: Geluk, Annemieke; Van Meijgaarden, Krista E; Franken, Kees L. M. C; Subronto, Yanri W; Wieles, Brigitte; Arend, Sandra M; Sampaio, Elizabeth P; Boer, Tjitske de; Faber, William R; Naafs, Ben; Ottenhoff, Tom H. M Title: Identification and characterization of the ESAT-6 homologue of mycobacterium leprae and T-cell cross-reactivity with mycobacterium tuberculosis ..- Source: s.l; s.n; May 2002. 5 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS REAÇOES CRUZADAS INTERFERON TIPO II HANSENIASE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS LINFOCITOS T TUBERCULOSE Location: BR191.1; 08648/s

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Id: 12238 Author: Maeda, Shinji; Matsuoka, Masanori; Nakata, Noboru; Kai, Masanori; Maeda, Yumi; Hashimoto, Ken; Kimura, Hiroaki; Kobayashi, Kazuo; Kashiwabara, Yoshiko Title: Multidrug resistant mycobacterium leprae from patients with leprosy ..- Source: s.l; s.n; Dec. 2001. 5 p. tab, graf. Descriptors: AGENTES ANTIINFECCIOSOS DE FLUOROQUINOLONA AGENTES ANTIINFECCIOSOS DE FLUOROQUINOLONA ANTIBIOTICOS ANTITUBERCULOSE ANTIBIOTICOS ANTITUBERCULOSE SEQUENCIA DE BASES PRIMERS DO DNA DNA BACTERIANO DNA BACTERIANO RESISTENCIA MICROBIANA A DROGAS RESISTENCIA A MULTIPLAS DROGAS GENES BACTERIANOS GENES BACTERIANOS LEPROSTATICOS LEPROSTATICOS HANSENIASE HANSENIASE CAMUNDONGOS DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE OFLOXACINA OFLOXACINA RIFAMPINA RIFAMPINA REACAO EM CADEIA POR POLIMERASE VIA TRANSCRIPTASE REVERSA Limits: ANIMAL Location: BR191.1; 08640/s

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Id: 12234 Author: Ohyama, Hideki; Matsushita, Sho; Nishimura, Fusanori; Kato, Nahoko; Hatano, Kentaro; Takashiba, Shogo; Murayama, Yoji Title: T cell responses to major membrane protein II (MMP II) of mycobacterium leprae are restricted by HLA-DR molecules in patients with leprosy ..- Source: s.l; s.n; 2001. 8 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS PROTEINAS DE BACTÉRIAS ANTIGENOS HLA-DR INTERFERON TIPO II INTERLEUCINA-5 HANSENIASE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE LINFOCITOS T Location: BR191.1; 08636/s

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Id: 12223 Author: Kremer, Laurent; Gurcha, Sudagar S; Bifani, Pablo; Hitchen, Paul G; Baulards, Alain; Morris, Howard R; Dell, Anne; Brennan, Patrick J; Besra, Gurdyal S Title: Characterization of a putative alpha-mannosyltranferase involved in phosphatidylinositol trimannoside biosynthesis in mycobacterium tuberculosis ..- Source: s.l; s.n; 2002. 11 p. ilus, graf. Descriptors: SEQUENCIA DE AMINOACIDOS DNA BACTERIANO GUANOSINA DIFOSFATO MANOSE LIPOPOLISSACARIDIOS MANOSILTRANSFERASES MANOSILTRANSFERASES DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM BOVIS MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS FOSFATIDILINOSITOIS ALINHAMENTO DE SEQUENCIA ESPECTROMETRIA DE MASSA DE BOMBARDEAMENTO RAPIDO Location: BR191.1; 08706/s

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Id: 12123 Author: Cole, S. T; Eigimeier, K; Parkhill, J; James, K. D; Thomson, N. R; Wheeler, P. R; Honore, N; Garnier, T; Churcher, C; Harris, D; Mungall, K; Basham, D; Brown, D; Chillingworth, T; Connor, R; Davies, R. M; Devlin, K; Duthoy, S; Feltwell, T; Fraser, A; Hamlin, N; Holroyd, S; Hornsby, T; Jagels, K; Lacroix, C; Maclean, J; Moule, S; Murphy, L; Oliver, K; Quail, M. A; Rajandream, M.-A; Rutherford, K. M; Rutter, S; Seeger, K; Simon, S; Simmonds, M; Skelton, J; Squares, S; Stevens, K; Taylor, K; Whitehead, S; Woodward, J. R; Barrell, B. G Title: Massive gene decay in the leprosy bacillus ..- Source: s.l; s.n; feb. 2001. 5 p. ilus, tab, graf. Descriptors: TATUS DNA BACTERIANO METABOLISMO ENERGÉTICO EVOLUÇAO MOLECULAR GENOMA BACTERIANO HANSENIASE DADOS DE SEQUENCIA MOLECULAR GENES REITERADOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE ANALISE DE SEQUENCIA DE DNA Transferência Genética Horizontal Limits: ANIMAL Location: BR191.1; 08699/s

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Id: 11944 Author: Visca, Paolo; Fabozzi, Giulia; Petrucca, Andrea; Ciaccio, Chiara; Coletta, Massimo; De Sanctis, Giampiero; Bolognesi, Martino; Milani, Mario; Ascenzi, Paolo Title: The truncated hemoglobin from Mycobacterium leprae ..- Source: s.l; s.n; 2002. 7 p. ilus, graf. Descriptors: MYCOBACTERIUM LEPRAE SEQUENCIA DE AMINOACIDOS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS SEQUENCIA DE BASES CLONAGEM MOLECULAR HEMOGLOBINAS HEMOGLOBINAS HEMOGLOBINAS LIGANTES MODELOS MOLECULARES DADOS DE SEQUENCIA MOLECULAR PROTEINAS RECOMBINANTES PROTEINAS RECOMBINANTES HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS Location: BR191.1; 08601/s

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Id: 11759 Author: Brahmbhatt, S; Hussain, R; Zafar, S; Dawood, G; Ottenhoff, Tom H. M; Drijfhout, J. W; Bothamley, G; Smith, S; Lopez, F. V; Dockrell, H. M Title: Human T cell responses to peptides of the Mycobacterium leprae 45-KD serine-rich antigen ..- Source: s.l; s.n; 2002. 9 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS LINHAGEM CELULAR EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T REINO UNIDO ANTIGENOS HLA-DR EPITOPOS IMUNODOMINANTES EPITOPOS IMUNODOMINANTES INTERFERON TIPO II HANSENIASE TUBERCULOIDE DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MYCOBACTERIUM LEPRAE PAQUISTAO PEPTIDIOS HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS SERINA LINFOCITOS T TUBERCULOSE PULMONAR CELULAS CULTIVADAS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08519/s

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Id: 11758 Author: Kremer, Laurent; Gurcha, Sudgar S; Bifani, Pablo; Hitchen, Paul G; Baulards, Alain; Morris, Howard R; Dell, Anne; Brennan, Patrick J; Besra, Grudyal S Title: Charaterization of a putative x-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis ..- Source: s.l; s.n; 2002. 10 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS DNA BACTERIANO GUANOSINA DIFOSFATO MANOSE LIPOPOLISSACARIDIOS MANOSILTRANSFERASES MANOSILTRANSFERASES DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM BOVIS MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS FOSFATIDILINOSITOIS ALINHAMENTO DE SEQUENCIA ESPECTROMETRIA DE MASSA DE BOMBARDEAMENTO RAPIDO TECNICAS DE FISIOTERAPIA/ED/MT MYCOBACTERIUM SMEGMATIS/EN Location: BR191.1; 08510/s

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Id: 11752 Author: Mempel, Martin; Flageut, Beatrice; Suarez, Felipe; Ronet, Catherine; Dubertret, Louis; Korisky, Philippe; Gachelin, Gabriel; Musette, Philippe Title: Comparasion of the T cell patterns in leprous and cutaneous sarcoid granulomas. Presence of Valpha24-invariant natural killer T cells in T-cell-reactive leprosy together with a highly biased t cell receptor Valpha repertoire ..- Source: s.l; s.n; 2000. 16 p. ilus, tab, graf. Descriptors: HANSENIASE DERMATOPATIAS DERMATOPATIAS DERMATOPATIAS PELE PELE PELE SEQUENCIA DE AMINOACIDOS BIOPSIA DNA DNA GRANULOMA GRANULOMA GRANULOMA IMUNOHISTOQUIMICA CÉLULAS KILLER NATURAIS CÉLULAS KILLER NATURAIS DADOS DE SEQUENCIA MOLECULAR RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA SARCOIDOSE SARCOIDOSE SARCOIDOSE ANALISE DE SEQUENCIA DE DNA LINFOCITOS T Location: BR191.1; 08522/s

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Id: 11729 Author: Nishimura, Masayuki; Kwon, Kyung Sool; Shibuta, Kenji; Yoshikawa, Yasuji; Oh, Chang-Keun; Suzuki, Tomokazu; Chung, Tae-Ahn; Hori, Yoshiaki Title: An improved method for DNA diagnosis of leprosy using formaldehyde-fixed, paraffin-embedded skin biopsies ..- Source: s.l; s.n; 1994. 4 p. ilus, tab. Descriptors: HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE SEQUENCIA DE BASES DNA BACTERIANO ELETROFORESE EM GEL DE AGAR FORMALDEIDO DADOS DE SEQUENCIA MOLECULAR INCLUSAO EM PARAFINA REAÇAO EM CADEIA POR POLIMERASE SEQUENCIAS REGULADORAS DE ACIDO NUCLÉICO SENSIBILIDADE E ESPECIFICIDADE PELE FIXAÇAO DE TECIDOS Location: BR191.1; 07218/s

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Id: 11607 Author: Williams, Diana L; Pittman, Tana L; Gillis, Thomas P; Matsuoka, Masanori; Kashiwabara, Yoshiko Title: Simultaneous detection of mycobacterium leprae and its susceptibility to dapsone using DNA heteroduplex analysis ..- Source: s.l; s.n; 2001. 6 p. tab, graf. Descriptors: SEQUENCIA DE BASES DNA BACTERIANO DNA BACTERIANO DAPSONA RESISTENCIA MICROBIANA A DROGAS LEPROSTATICOS HANSENIASE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE SENSIBILIDADE E ESPECIFICIDADE ANALISE DE SEQUENCIA DE DNA ANALISE HETERODUPLEX/*MT Location: BR191.1; 08430/s

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